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Acetonitrile or methyl cyanide is a highly volatile, aprotic polar organic solvent. Acetonitrile is used in analytical chemistry as a solvent or mobile phase. It is also utilized as a solvent in organic reactions such as the synthesis of alkyl hydroperoxides by oxidizing alkane with hydrogen peroxide in the presence of iron complexes.

Acetonitrile is also used in pharmaceuticals for drug synthesis, purification, and formulation. It is particularly useful for drugs that are poorly soluble in water or other common solvents.